OUR PLATFORM
>>Modular >>Versatile >>Cost-Effective
>> Through rational protein design and engineering we have turned viral proteins into self-assembling scaffolds.
>> Self-assembly is fully controllable. These scaffolds oligomerize into homogeneous, reproducible monodisperse ring-like particles.
>> These proteins can be used as scaffolds fused to cargoes of different functionalities. Thus, we can generate libraries of functionalities that can be integrated on-demand, enabling combinatorial design.
>> The topology and orientation of the cargoes can be controlled to maximize display, ligand binding, receptor engagement or complex formation.>>??as
This technology allows the creation of soluble, stable, multivalent, multicomponent and multifunctional particles.
A versatile application-agnostic technology
We have generated multiple building blocks, including:
>> Adjuvants that activate the innate immunity, enhancing both the cellular and humoral adaptive responses leveraging on the physical linkage between adjuvants and antigens.
>> Antigens, including model antigens, antigens from respiratory viruses, and conformational epitopes relevant in neurodegenerative diseases.
>> Functionalizable cargoes that enhance the nanoarchtectonic capabilities of the platform, enabling the incorporation of biotinylated ligands and antibodies.
>> Probes and reporters for multifunctional biotools, detection and diagnostics.
>> Minibinders and polytopes for epitope recognition or serological diagnostics, respectively.
This library enables combinatorial design through on-demand combination and self-assembly for the creation of customizable products